2008年

　原著

• Harada, B. T., Knight, M. J., Imai, S., Qiao, F., Ramachander, R., Sawaya, M. R., Gingery, M., Sakane, F. and Bowie, J. U. Regulation of enzyme localization by polymerization: Polymer formation by the SAM domain of diacylglycerol kinase δ1.Structure 16 (3), 380–387 (2008)

 

• Chibalin, A. V., Leng, Y., Vieira, E., Krook, A., Björnholm, M., Long, Y-C., Kotova, O., Zhong, Z., Sakane, F., Steiler, T., Nylén, C., Wang, J., Laakso, M., Topham, M. K., Gilbert, M., Wallberg-Henriksson, H. and Zierath, J. R. Down-regulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance.Cell 132 (3), 375–386 (2008)

 

• Yasuda, S., Kai, M., Imai, S., Kanoh, H. and Sakane, F. Phorbol ester and hydrogen peroxide synergistically induce the interaction of diacylglycerol kinase γ with the Src homology 2 and C1 domains of β2-chimaerin. Biochem. J. 409 (1), 95–106 (2008)

 

• Kawakami, A., Sakane, F., Imai, S., Yasuda, S., Kai, M., Kanoh, H., Jin, H-Y., Hirosaki, K., Yamashita, T., Fisher, D. E. and Jimbow, K. Rab7 regulates maturation of the melanosomal matrix protein gp100/Pmel17/Silv. J. Invest. Dermatol. 128 (1), 143–150 (2008)

 

　総説・著書

• Sakane, F., Imai, S., Kai, M., Yasuda, S. and Kanoh, H. Diacylglycerol kinases as emerging potential drug targets for a variety of diseases. Special issue “Peripheral proteins as drug targets”. Curr. Drug Targets 9 (8), 626–640 (2008)

 

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2007年

　原著

• Miele, C., Paturzo, F., Teperino, R., Sakane, F., Fiory, F., Oriente, F., Ungaro, P., Valentino, R., Beguinot, F. and Formisano, P. Glucose regulates diacylglycerol intracellular levels and protein kinase C activity by modulating diacylglycerol-kinase subcellular localization. J. Biol. Chem. 282 (44), 31835–31843 (2007)

 

• Kai, M., Yasuda, S., Imai, S., Kanoh, H. and Sakane, F. Tyrosine phosphorylation of β2-chimaerin by Src-family kinase negatively regulates its Rac-specific GAP activity. Biochim. Biophys. Acta - Mol. Cell Res. 1773 (9), 1407–1415 (2007)

 

• Yasuda, S., Kai, M., Imai, S., Kanoh, H. and Sakane, F. Diacylglycerol kinase γ interacts with and activates β2-chimaerin, a Rac-specific GAP, in response to epidermal growth factor. FEBS Lett. 581 (3), 551–557 (2007)

 

• Yanagisawa, K., Yasuda, S., Kai, M., Imai, S., Yamada, K., Yamashita, T., Jimbow, K., Kanoh, H. and Sakane, F. Diacylglycerol kinase α suppresses tumor necrosis factor-α-induced apoptosis of human melanoma cells through NF-κB activation. Biochim. Biophys. Acta - Mol. Cell Biol. Lipids 1771 (4), 462–474 (2007)

 

　総説・著書

• Sakane, F., Imai, S., Kai, M., Yasuda, S. and Kanoh, H. Diacylglycerol kinases: Why so many of them? Biochim. Biophys. Acta - Mol. Cell Biol. Lipids 1771 (7), 793–806 (2007)

 

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2006年

　原著

• Kai, M., Sakane, F., Jia, Y-J., Imai, S., Yasuda, S. and Kanoh, H. Lipid phosphate phosphatases 1 and 3 are localized in different lipid rafts. J. Biochem. 140 (5), 677–686 (2006)

 

• Crotty, T., Cai, J., Sakane, F., Taketomi, A., Prescott, S. M. and Topham, M. K. Diacylglycerol kinase δ regulates protein kinase C and epidermal growth factor receptor signaling. Proc. Natl. Acad. Sci. U. S. A. 103 (42), 15485–15490 (2006)

 

• Matsubara, T., Shirai, Y., Miyasaka, K., Murakami, T., Yamaguchi, Y., Ueyama, T., Kai, M., Sakane, F., Kanoh, H., Hashimoto, T., Kamada, S., Kikkawa, U. and Saito, N. Nuclear transportation of diacylglycerol kinase γ and its possible function in the nucleus. J. Biol. Chem. 281 (10), 6152–6164 (2006)

 

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2005年

　原著

• Imai, S., Kai, M., Yasuda, S., Kanoh, H. and Sakane, F. Identification and characterization of a novel human type II diacylglycerol kinase, DGKκ. J. Biol. Chem. 280 (48), 39870–39881 (2005)

 

• Regier, D. S., Higbee, J., Lund, K. M., Sakane, F., Prescott, S. M. and Topham, M. K. Diacylglycerol kinase ι regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signaling. Proc. Natl. Acad. Sci. U. S. A. 102 (21), 7595–7600 (2005)

 

• Toya, M., Hozumi, Y., Ito, T., Takeda, M., Sakane, F., Kanoh, H., Saito, H., Hiroi, M., Kurachi, H., Kondo, H. and Goto, K. Gene expression, cellular localization and enzymatic activity of diacylglycerol kinase isozymes in rat ovary and placenta. Cell Tissue Res. 320 (3), 525–533 (2005)

 

• Katagiri, Y., Ito, T., Saino-Saito, S., Hozumi, Y., Suwabe, A., Otake, K., Sata, M., Kondo, H., Sakane, F., Kanoh, H., Kubota, I. and Goto, K. Expression and localization of diacylglycerol kinase isozymes and enzymatic features in rat lung.Am. J. Physiol. Lung Cell Mol. Physiol. 288 (6), 1171–1178 (2005)

 

　総説・著書

• 坂根郁夫．ダイナミックに新展開する脂質研究：ジアシルグリセロールキナーゼとホスファチジン酸ホスファターゼの多彩な生理機能．実験医学　23 (6), 847－857 (2005)

 

• 坂根郁夫，山田恵子，加納英雄．ジアシルグリセロールキナーゼ．石橋貞彦，市川厚，堅田利明編．生物薬科学実験講座　第7巻　情報伝達物質 [II] シグナル伝達系と細胞機能　第４章 酵素活性　3. 脂質代謝酵素，pp. 403－414，廣川書店，東京（2005）

 

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2004年

　原著

• Imai, S., Kai, M., Yamada, K., Kanoh, H. and Sakane, F. The plasma membrane translocation of diacylglycerol kinase δ1 is negatively regulated by conventional protein kinase C-dependent phosphorylation at Ser-22 and Ser-26 within the pleckstrin homology domain. Biochem. J. 382 (3), 957–966 (2004)

 

• Tsushima, S., Kai, M., Yamada, K., Imai, S., Houkin, K., Kanoh, H. and Sakane, F. Diacylglycerol kinase γ serves as an upstream suppressor of Rac1 and lamellipodium formation. J. Biol. Chem. 279 (27), 28603–28613 (2004)

 

• Ito, T., Hozumi, Y., Sakane, F., Saino-Saito, S., Kanoh, H., Aoyagi, M., Kondo, H. and Goto, K. Cloning and characterization of diacylglycerol kinase ι splice variants in rat brain. J. Biol. Chem. 279 (22), 23317–23326 (2004)

 

 

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2003年

　原著

• Jia, Y-J., Kai, M., Wada, I., Sakane, F. and Kanoh, H. Differential localization of lipid phosphate phosphatases 1 and 3 to cell surface subdomains in polarized MDCK cells. FEBS Lett. 552 (2–3), 240–246 (2003)

 

• Murakami, T., Sakane, F., Imai, S., Houkin, K. and Kanoh, H. Identification and characterization of two splice variants of human diacylglycerol kinase η. J. Biol. Chem. 278 (36), 34364–34372 (2003)

 

• Yamada, K., Sakane, F., Imai, S., Tsushima, S., Murakami, T. and Kanoh, H. Regulatory role of diacylglycerol kinase γ in macrophage differentiation of leukemia cells. Biochem. Biophys. Res. Commun. 305 (1), 101–107 (2003)

 

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2002年

　原著

• Sakane, F., Imai, S., Yamada, K., Murakami, T., Tsushima, S. and Kanoh, H. Alternative splicing of the human diacylglycerol kinase δ gene generates two isoforms differing in their expression patterns and in regulatory functions. J. Biol. Chem. 277 (45), 43519–43526 (2002)

 

• Imai, S., Sakane, F. and Kanoh, H. Phorbol ester-regulated oligomerization of diacylglycerol kinase δ linked to its phosphorylation and translocation. J. Biol. Chem. 277 (38), 35323–35332 (2002)

 

　総説・著書

• Kanoh, H., Yamada, K. and Sakane, F. Diacylglycerol kinases: Emerging downstream regulators in cell signaling systems. J. Biochem. 131 (5), 629–633 (2002)